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GLP-1R activation by retatrutide promotes glucose-dependent insulin secretion, suppresses glucagon during hyperglycemia, delays gastric emptying, and reduces appetite via CNS signaling

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PMID 17070848

Key Takeaways Retatrutide is a once-weekly injectable triple agonist targeting GLP-1, GIP, and glucagon receptors Starting dose is typically 1 mg weekly, titrating up gradually to minimize side effects Maintenance doses range from 8 mg to 12 mg weekly based on individual response Titration is critical for balancing weight loss efficacy with tolerability Clinical trials show significant weight reduction compared to placebo Always work with a healthcare provider to determine your optimal dosing schedule Overview of Retatrutide What is Retatrutide