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Abbreviations CT: Computed Tomography ECG: Electrocardiography ED: Emergency Department GH: Growth Hormone HGH: Human Growth Hormone LA: Left Atrium LVH: Left Ventricular Hypertrophy PE: Pulmonary Embolism References Ranke MB, Wit JM

Discontinuation studies show that patients typically regain a substantial portion of lost weight within one year of stopping medication, accompanied by return of appetite and metabolic parameters toward baseline

Additionally, metabolic profiling has revealed that suppression of GLS1 induces a compensatory anaplerotic mechanism via pyruvate carboxylase (PC), which allows the release of a glutamine-independent supply of TCA intermediates by catalyzing the transformation of pyruvate to oxaloacetate 153

Tesamorelin holds FDA approval for HIV-associated lipodystrophy based on two Phase 3 RCTs (Falutz et al., 2007 and 2010) showing roughly 15 to 18 percent visceral adipose tissue reduction versus placebo at 26 weeks