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Patients considering these medications should discuss their history of gastrointestinal issues with their healthcare provider to set realistic expectations and develop strategies for managing potential side effects during the critical early treatment period

These enzymes are involved in detoxification processes 25 by linking toxic compounds with glutathione (GSH), a key antioxidant non-protein thiol, thus counteracting oxidative stress 26

Numerous studies have identified many target genes of NRF2 and revealed functions of pleiotropic NRF2 in addition to its redox-regulating function

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