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A similar trend was observed in REWIND, where sustained benefits emerged with extended treatment exposure, suggesting that younger people, by virtue of prolonged therapy duration, may accrue a greater cumulative benefit from GLP-1 RAs [41], potentially explaining the more marked death reduction observed in this subgroup within our study
Their review, however, identified no studies stratifying the potential role of GLP-1 RAs across overlapping dermatologic and rheumatologic conditions, suggesting that future multidisciplinary trials should incorporate these factors
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