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Figure 2 Discussion Accumulating evidence suggests that the relationship between GLP-1 RAs and the gut microbiome may extend beyond a simple secondary consequence of weight loss or glycemic improvement, although the relative contribution of direct pharmacological effects versus indirect metabolic changes remains incompletely defined

While under pathological conditions, oxygen reacts with excess labile iron and generates ROS that attacks lipid membrane, implicated in lipid peroxidation (Han et al., 2020)