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First developed in the early 2000s to treat type 2 diabetes by mimicking the action of the naturally occurring hormone glucagon-like peptide 1, GLP-1 receptor agonists have since been shown to have a positive and significant impact on obesity, other medical conditions and biological functions

One is Virta Health, which advertises its nutrition-focused weight management program as "a proven approach for deprescribing GLP-1s when clinically appropriate." A Virta-funded study assessed 154 people with Type 2 diabetes who stopped using GLP-1 medications but continued following Virta's program, concluding that their weight did not significantly increase after a year