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were supported by NIH grants P01 (CA217797) and P30 (CA086862)

However, their long life-span, penetration through the bloodbrain barrier (BBB) 13 , and high therapeutic doses may allow them to directly act on central nervous system GLP-1Rs 12 , thereby causing CNS-dependent side effects

Insulin-like Growth Factor (IGF-1 Long-Arginine 3), an 83-amino acid analog of IGF-1, is a highly anabolic hormone released primarily in the liver with the stimulus of growth hormone (HGH) [1]