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The stabilization and nuclear translocation of Nrf2 result in the transcription of antioxidant response element-regulated genes such as HO-1, NQO1, GCLC, SOD, catalase, and GPx, which together enhance glutathione synthesis, maintain mitochondrial redox balance, suppress lipid peroxidation, and improve cellular resilience to oxidative insults

Non-alcoholic fatty liver disease: a risk factor for myocardial dysfunction

10.1016/j.neuron.2010.11.040 306 ShawP

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