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A prospective clinical trial indicated that, compared with the control group, liraglutide significantly increased activation in the dorsolateral prefrontal cortex and orbitofrontal cortex regions of the brain

Conversely, some exhibit chronic cognitive impairment in absence of measurable neuropathology, prompting interest into cognitive resilienceretained cognition despite significant neuropathologyand cognitive frailtyimpaired cognition despite low neuropathology

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The magnitude of the absolute risk reduction was also larger than expected