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doi: 10.1007/s10875-019-00638-z 69 LachmannHJLowePFelixSDRordorfCLeslieKMadhooSet al

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Tirzepatide in Clinical Trials Comparing safety head-to-head shows both medications have similar tolerability profiles, though tirzepatide's dual GLP-1/GIP action may cause slightly higher gastrointestinal effects at initiation

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Constipation: In some cases, constipation may occur, though it is generally less common than other gastrointestinal issues

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