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Structural brain changes may already occur even before dementia manifests itself

However, this effect was not sustained upon cessation of the treatment [79]

These findings may inform appropriate expectation setting for patients and clinicians and highlight the need for better methods of treatment selection for patients with degenerative lumbar spinal stenosis. Surgery caused adjacent segment disease A December 2025 study ( 20 ) explained that lateral lumbar interbody fusion (LLIF) works by indirectly providing decompression by restoring disc height

People with a history of stomach problems, like gastritis or ulcers, may experience more side effects