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Representative immunohistochemistry (b) and immunofluorescence (c) staining of indicated proteins in Gclc WT and Gclc KO mammary tumors (Scale bar = 50 m)

PERK induces the translation of ATF4, which induces the expression of the transcription factor C/EBP homologous protein (CHOP) (264)

It upregulates the expression of early growth response protein 1 (EGR-1), a transcription factor that controls over 30 downstream genes involved in cytokine production, growth factor signaling, and extracellular matrix remodeling

No association was demonstrated between vitamin C, vitamin E, copper, or manganese intake and hypertensive disorders