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(PubMed) Bauman WA, Shaw S, Jayatilleke E, Spungen AM, Herbert V

Any compound that potentiates this pathway carries a theoretical risk of promoting neoplastic processes (PMID: 34179015) No Chronic Toxicity Data: Long-term effects of sustained HGF/c-Met potentiation are unstudied even in animal models Uncharacterized Dose-Response: The relationship between Dihexa dose and adverse effects in any living system is poorly defined beyond acute preclinical studies No Regulatory Review: Dihexa has never undergone the systematic safety evaluation required for regulatory submission Safety Comparison Summary: Cerebrolysin has a known, well-characterized safety profile from decades of clinical use

Secondary outcomes included the pharmacokinetic profile of PG-102, assessed using serum concentrationtime data and non-compartmental analyses, with exploratory pharmacodynamic and biomarker endpoints

At lower doses, the increases were proportionally smaller, generally ranging from 2 to 5 beats per minute depending on the specific dose and titration schedule