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I get a lot of pushback on that from physicians saying, Why would you want to burden a patient with that knowledge? I welcome that debate because it opens a discussion: Do you or do you not believe that this a deterministic gene

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For translational confidence, studies should include prolonged follow-up (weeks to months), dose-fractionation schedules that mimic chronic dosing, aged animals or disease models, and paired clearance experiments to quantify retention and excretion routes (170)