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Re-evaluate long-term need often and work with knowledgeable clinicians to mitigate risks and adjust dosing according to response and goals

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The Evidence Multiple large cardiovascular outcome trials have demonstrated GLP-1 medications reduce heart attacks, strokes, and cardiovascular death: SUSTAIN-6 (semaglutide): 26% reduction in major adverse cardiovascular events (MACE) in patients with Type 2 diabetes and high cardiovascular risk