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Exendin-4 increases mRNA expression of Il1b, Il6, Il22, Il12b, Tnfa, Ccl2, Cxcl1 , and Cxcl2 (innate immunity), regenerating islet-derived protein 2, RegIIIy and RegIIIB (anti-microbial proteins), as well as Il-5, Il-13 (pathogen clearance) within 4 h of administration, returning to baseline expression by 24 h (Yusta et al., 2015), suggesting that GLP-1R activation engages a cytoprotective response