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Mutations in the transcobalamin gene can cause a deficiency

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Magnetic beadbased purification is preferred when: Samples are small or low-abundance Fast turnaround is required Minimal equipment is desired High-throughput or automated workflows can be used Traditional methods (e.g., affinity chromatography, ion exchange, filtration) are more suitable for large-scale or preparative protein purification, where higher binding capacity is needed

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