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[DOI] [PubMed] [Google Scholar] 27.Perusse R, Morency R

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The TMAO treatment induced the hypertrophy of cultured cardiomyocytes and expression of hypertrophic markers such as atrial natriuretic peptide (ANP) and beta-myosin heavy chain (-MHC) that was demonstrated to be mediated via TGF-/Smad3 signaling that had been identified in the development of cardiac hypertrophy and fibrosis