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A randomized (159), double-blind, placebo-controlled trial involving 46 adult SLE patients (23 in the synbiotic group, 23 in the placebo group) showed that 60 days of synbiotic supplementation significantly increased butyrate metabolism, reduced the pro-inflammatory cytokine IL-6, and inhibited the elevation of hs-CRP

doi: 10.1038/nrdp.2017.60 87 GukovskayaASGukovskyIAlglHHabtezionA

Additionally, glutathione disulfide (GSSG) is involved in the degradation of drug delivery systems containing disulfide bonds, which allows for targeted drug release in cancer therapy

* Daily Basal Insulins: The primary shift will be patients moving away from once-daily basal insulins, such as insulin glargine, to this new once-weekly alternative