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When these effects were studied using cocaine, Ex-4 increased MSN action potential (AP) frequency in the NAc core and shell following the extinction of cocaine self-administration without changing sEPSC frequency or PPR or sEPSC, which indicated that increased excitability of MSNs in NAc might be contributing to suppressive effects of Ex-4 and this is a mechanism independent of the presynaptic stimulation (Hernandez et al., 2019)