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PIO, GLP-1R agonists, SGLT2 inhibitors and NAFLD: pathophysiological background PIO PIO, currently the only thiazolidinedione (TZD) in clinical practice, is a potent exogenous agonist of the nuclear peroxisome proliferator-activated receptor-gamma (PPAR-) and to a lesser extent, PPAR- [17, 44]

Oxidative stress Oxidative stress is a pivotal mechanism behind ECD [99, 100], consisting of an imbalance of the redox state due to reactive oxygen species (ROS) overproduction, antioxidant systems depletion, or both

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Testosterone levels naturally rise in response to sexual arousal and activity, so it makes sense that men with higher testosterone levels usually have more frequent and intense sexual activity