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Methylcobalamin is required for the creation of S-adenosylmethionine (SAM), the most important methyl donor in the human body

Rogers TF, Zhao F, Huang D et al (2020) Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

However, in the absence of TH, due to a different structural conformation in the unliganded state, the TRs recruit a co-repressor complex (Co-R) with histone deacetylase activity (HDAC) that induces a repressive chromatin environment to prevent transcription of target genes