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A key enzyme in the anabolic utilization of ketone bodies is cytosolic acetoacetyl-CoA synthetase, which catalyses the coupling of acetoacetate to CoA in a reaction dependent on ATP with acetoacetyl-CoA as the product

c , Western blot of HT1080 OE GFP-GPX4 WT and HT1080 OE GFP-GPX4 R152H after treatment with ferroptosis inducers with GPX4 and GAPDH antibodies, with lanes arranged for ferroptosis inducer comparison

Research published in PubMed Central explains that transdermal absorption is generally effective only for small molecules