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GLP-1 drugs were originally developed to treat type 2 diabetes, but several are now approved for chronic weight management: Wegovy (semaglutide), which is available as a pill or injection Zepbound (tirzepatide) injection Saxenda (liraglutide) injection Impact of Obesity on MS Progression Benefits of Weight Loss for People With MS Together, these findings suggest that weight loss may positively influence inflammation and symptoms relevant to MS, even though long-term effects on disease progression are still unclear, says Ali

140 (Table 2) It is increasingly recognized that disturbances in urate transport, both in the gastrointestinal tract and kidneys, are pivotal in the pathogenesis of diseases associated with hyperuricemia

Gastrointestinal effects and travel The most common GLP-1 side effects involve the digestive system

The Pediatric Neurology Advisory Committee in 1996 and some textbooks and manuals strongly recommended carnitine supplementation (50100 mg/kg per day) during VPA therapy for children at risk for developing a carnitine deficiency, in VPA overdose and in VHT [33, 92, 93]