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Higher concentrations of glycochenodeoxycholic acid, glycodeoxycholic acid, hyodeoxycholic acid, and certain bile acid ratios were associated with patient CSF tau and p-tau

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Kiechl S, Wittmann J, Giaccari A, Knoflach M, Willeit P, Bozec A, et al

Potential limitations of both studies include the use of a single dose rather than multiple doses of cagrilintide and the use of doses (0.6 mg in the renal impairment study and 0.9 mg in the hepatic impairment study) lower than the 2.4 mg dose being evaluated in clinical development