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PMC 4108183

A comprehensive panel of primary antibodies was used to detect various proteins: FOXO4, p53, Ser15-phospho-p53, p21 (cyclin-dependent kinase inhibitor 1A), p16 (cyclin-dependent kinase inhibitor 2A), 3-HSD, CYP11A1, CYP17A1 (cytochrome P450 family 17 subfamily A member 1), and several senescence-associated secretory phenotype (SASP) factors including IL-1, IL-1, IL-6, IL-10, TNF-, and TGF-

8,9 BI 3034701 is a potential first-in-class triple agonist designed to activate the GLP1, GIP, and NPY2 receptors

Companies seeking to sell generics also may strike deals with branded companies that delay their market entry