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These PTMs are involve in various pathological events or diseases such as inflammation, carcinogenesis, aging, and neurodegenerative disorders (5961)

However, if lifestyle approaches are insufficient, healthcare practitioners should discuss initiating pharmacotherapy, such as GLP-1 receptor agonists, while recognising the limitations of reimbursement and supply

A portfolio of drugs can be aggregated across this framework to produce a total LOE exposure figure: the difference between the un-adjusted portfolio NPV (assuming no LOE erosion) and the IP-adjusted NPV (applying expected erosion to each asset)

However, in the brain of neurodegenerative diseases, the excess production of ROS and NO results in neuronal damage 7,8,9