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Venous irritation: When given intravenously (after proper dilution with solute), there is a risk of phlebitis or thrombosis (vein inflammation or clot at the injection site), especially if the osmolarity of the admixture is not close to physiologic

7 The mechanisms of IGF-1 for enhancing tendon regenerative healing Although the aforementioned studies demonstrate the therapeutic potential of IGF-1 in promoting tendon regenerative healing in vivo , the underlying mechanisms remain incompletely understood