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(2010) identified spadin (the parent compound) as a natural TREK-1 blocker and demonstrated antidepressant-like effects in behavioral models

In obese mouse models: Animals treated with 5-Amino-1MQ lost significant fat mass compared to controls Effects were most pronounced in visceral adipose tissue the metabolically dangerous fat around organs No cardiovascular toxicity or significant off-target effects were observed at research doses Body weight decreased without appetite changes, suggesting the mechanism was purely metabolic Human data is limited this is still a research compound

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