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Recent evidence showed that Tirzepatide (TZP), a new drug including both Glucagon Like Peptide 1 (GLP-1) and Glucose-dependent Insulinotropic Polypeptide (GIP) receptor agonism, is effective in subjects with type 2 diabetes (T2D), lowering body weight, fat mass and glycated hemoglobin (HbA 1c ) also in obese or overweight adults without T2D

DSIP inhibited hypothalamic somatostatin (SRIF) release in a dose-dependent fashion in rats

Impulse control disorders such as compulsive shopping, compulsive eating, gambling and hypersexuality are associated with dopamine agonists

Sarcopenia is common among older adults with obesity and NASH patients with cirrhosis leading to increased risk for lower bone density, decreased strength and mortality