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Though doses of up to 2,000 mcg of vitamin B12 are considered safe, its best to speak with a doctor to find out whether taking a supplement is necessary

The mechanism behind the possible influence of B12 on the circadian rhythm is not clear, but there is evidence to suggest that B12 may increase the light sensitivity of the circadian clock

If the powder does not dissolve immediately, let the vial sit at room temperature for a few minutes and try gentle swirling again

Disruption of the BBB is observed in many neurological disorders, including multiple sclerosis, stroke, Alzheimers disease, epilepsy, and traumatic brain injury, and is frequently induced by neuroinflammation [1]