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Both liraglutide and semaglutide have received FDA approval for the treatment of T2DM, obesity, and cardiovascular risk reduction [ Table 2 ]

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In mice with diet-induced obesity, oral supplementation of 400mg/kg of butyrate improved glucose tolerance and increased the expression of phosphorylated adenosine monophosphate kinase (AMPK) as well as glucose transporter-4 in the adipose tissue, and reversed some of the gut microbiota alterations caused by the high-fat diet (HFD) (85)

More recent research has explored AOD9604 for other potential applications beyond obesity, including osteoarthritis treatment based on observations of cartilage regeneration properties in preclinical models, though clinical validation of these additional indications is limited