decoding glp-1 glp 1 GLP-1: A Guide for Friends and Family of Those On The Pen Glucagon-Like Peptide-1: New Regulator in

Petrie M, Borlaug B, Buchholtz K et al (2024) HERMES: effects of ziltivekimab versus placebo on morbidity and mortality in patients with heart failure with mildly reduced or preserved ejection fraction and systemic inflammation

Septerna has developed a native complex platform that can reconstitute the GLP-1 receptor within an artificial lipid bilayer, complexed with combinations of drug and internal cell signalling molecules, which replicates the dynamics of the signalling process at scale

BJT-778 showed the highest binding affinity to FcRI and FcRIIIa which was correlated with expression on cMono, iMono, and mDCs

A comprehensive review published in Frontiers in Endocrinology (2024) further confirms that GLP-1 drugs reshape gastrointestinal physiology and metabolic regulation at multiple levels, affecting far more than just appetite