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For its part, canagliflozin led to reductions in HF-associated symptoms in the CHIEF-HF24 study (476 patients, 12-week follow-up), regardless of the EF or the presence of diabetes mellitus (DM)

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Treatment goals for nausea management are directed to prevent serious complications of persistent vomiting that could lead to hypovolemia and vitamin deficiencies that could lead to more serious conditions including but not limited to renal failure, cardiac abnormalities and electrolyte imbalances that could be fatal