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Typical onset: 24 to 72 hours after the first injection, or 24 to 72 hours after any dose increase

Consider skipping your dose if you have: Severe diarrhea (more than 6 loose stools in 24 hours) Persistent vomiting preventing fluid retention Severe abdominal cramping or pain Signs of dehydration despite drinking fluids Hydration Strategies During Illness Staying hydrated while sick on GLP-1 medications requires extra attention and strategy

Why you might not feel hungry enough The opposite problem, appetite suppression so intense that eating feels impossible, is equally concerning and often gets less attention

This means eating healthy, exercising regularly, and staying consistent with GLP-1 weekly injections