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This hormone, produced in the pineal gland, has several jobs, including regulating our circadian rhythm, maintaining cell function, and supporting our energy levels

Online Metabolic & Molecular Bases of Inherited Disease, The McGraw-Hill Companies, New York 2001:3897-933 6

Chen WW, Zhang X, Huang WJ

In a long-term randomized, double-blind, placebo-controlled study among sufferers of cerebrovascular accidents at high risk of depression, daily supplementation with 2 mg of folic acid, 25 mg of vitamin B6, and 500 g vitamin B 12 significantly lowered the risk of major depressive episodes during a seven-year follow-up period compared to placebo (111)