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If you experience weight gain or plateau despite adherence, genetic testing through PlexusDx Precision Peptide Genetic Test ($99 add-on after first month) can reveal whether your body is a candidate for dose escalation, dual-compound therapy like GLP-Squared, or a switch to tirzepatide

It may occur abruptly or over a longer duration and is accompanied by a burning sensation in the mouth

Once a month injections may be required

By engaging all three pathways simultaneously, retatrutide is designed to produce a more pronounced effect on body weight and metabolic health than single or dual agonists, though direct head-to-head comparative trials have not yet been conducted