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Although the exact composition of these multi-molecule complexes depends on the activator, they classically comprise a NOD-like receptor (NLR) that acts as a sensor, such as NLRP3 and NLRP1, the adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC, also referred to as PYCARD) and the catalytic protein caspase 1 (CASP1) [8]

Because most plasma GSH originates in hepatocytes, the authors hypothesized that decreased plasma GSH also could signify intracellular depletion