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Alcon, M

269 BCAA uptake is dependent on the type I amino acid transporter LAT, and mutations in SLC7A5 and SLC3A2, members of the LAT family, impair BCAA uptake by T cells and inhibit the proliferation and differentiation of Th1, Th17, and CTL cells

Antioxid Redox Signal 7:16301647 Li Y, Xu Y, Lei B et al (2012) Rhein induces apoptosis of human gastric cancer SGC-7901 cells via an intrinsic mitochondrial pathway

In the KEYNOTE-355 trial, pembrolizumab combined with chemotherapy significantly extends OS in patients with metastatic TNBC with a CPS 10, making it the first immunotherapy to achieve this