Currently, once-weekly subcutaneous semaglutide 2.4 mg is approved for chronic weight management in adults with obesity, or overweight and with at least one weight-related comorbidity 17 , for reducing CV risk in adults with established cardiovascular disease (CVD) with obesity or overweight 18 , and in adolescents aged 12 years and older 19 , in conjunction with a reduced-calorie diet and increased physical activity plan
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Not all patients qualify, and results vary
WHO is currently working on a rapid advice guideline on possible use of GLP-1 RAs, including semaglutides, for treatment of obesity in adults and as part of a more comprehensive model of care