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It is estimated that about 40,000 to 100,000 people worldwide die annually due to amoebiasis Since amoebiasis is transmitted through contaminated food and water, it is often endemic in regions of the world with limited modern sanitation systems, including Mxico, Central America, western South America, South and Southeast Asia, and western and southern Africa

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11qIn addition, lower plasma levels of proteins belonging to the ribosome (Rps2p, Rps9p, Rps24p, Rpl15p) and proteasome (PSMC3, PSMA3, PSMD12, PSMD1, PSMD2, PSMD11, PSMA7, PSMC4, PSMB1, PSMA2, PSMA1, PSMC5, PSMA6, PSMD7) pathway were also identified (Table 1)

13 Modern medical research indicates that proteolytic enzymes extracted from durian juice and rind can be used clinically as anti-edema and anti-inflammatory drugs