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Summary: Various tests measure B12 status, including plasma B12, homocysteine, MMA and holoTC

While that gap is meaningful, it was not dramatic enough for AOD-9604 to win approval as a standalone obesity drug, and formal development was paused in 2007

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Finally, although the correlations between the metabolome and microbiome were established using robust statistical analyses, there was limited statistical power and there are also limitations to the statistical approaches used herein (e.g., log transformation to resolve non-normal distribution and/or heteroscedasticity 103 )