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However, the control group (PSP0, Fig

Mechanistically, LONP1 silencing not only reduces cellular bioenergetic capacity but also decreases the LC3-II/I ratio and PINK1/Parkin levels, thereby suppressing mitophagy [169, 170] (Fig

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After absorption, GA is transported to the liver primarily via carrier-mediated mechanisms and undergoes phase II metabolism to form glucuronide and sulfate conjugates (Ploeger et al., 2001)