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Calgarys Christina Saviskoff, a recreational runner in her 40s with diabetes, began using Ozempic after a sudden drop in both endurance and blood sugar control

In phentermine and topiramate extended-release clinical trials, the peak reduction in serum bicarbonate typically occurred within 4 weeks of titration to the assigned dose, and in most patients, there was a correction of bicarbonate by week 56, without any dosage reduction

This fundamental difference in mechanism means direct pharmacological interaction between the two compounds is unlikely

Dina Hirsch, Northwell Healths clinical director of bariatric psychology and behavioral weight management, said in an email GLP-1 drugs, which work to reduce weight in part by quieting repetitive thoughts about eating, may have "neuroprotective and anti-inflammatory effects" that make them effective treatments for depression