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Although a number of therapeutic approaches have been used for women with presumed extrapelvic endometriosis, the reported efficacy of ovarian suppression with a GnRH agonist appears to support it as the first line of therapy except in cases of obstruction of the ureter or bowel, which are best treated surgically (38)

Collectively, these changes result in irreversible cell cycle arrest, increased secretion of pro-inflammatory cytokines and matrix-degrading enzymes, amplifying inflammation and oxidative stress in renal tissue

Intracellular lipid peroxide (LPO) detection To detect the intracellular LPO content, 143B cells were incubated with PBS, Ru(II)-OH, NP2, and NP4 (Ru 10 M) for 6 h