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Women who are pregnant, planning pregnancy, or breastfeeding should avoid the compound entirely due to unknown effects on fetal and infant development

But the question remains: how much semaglutide should you take to achieve these benefits

Questions That Often Come Up Before Starting People often want to know how quickly they will see results, whether the weight comes back after stopping, and how GLP-1 medications compare to other weight loss treatments

A 2025 meta-analysis in Diabetes, Obesity and Metabolism confirmed that across SURMOUNT-1 to -4, GI adverse events with tirzepatide ranged from 27.8% to 72.8% (any GI event) versus 12.2% to 32.5% on placebo, with discontinuation due to GI symptoms running 1.0% to 10.5%