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Park et al suggested that the anti-proliferative and pro-apoptotic effects of quercetin might be achieved through regulation of MAPK and PI3K/Akt signaling pathway transduction

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PLoS ONE 11(2):e0148172 Markic J, Krzelj V, Markotic A, Marusic E, Stricevic L, Zanchi J, Sapunar A (2006) High incidence of glucose-6-phosphate dehydrogenase deficiency in Croatian island isolate: example from Vis island

In the case of aging, it is known that over time, mitochondrial dysfunction occurs in parallel with NAD + depletion in muscle tissues, and often this depletion has been linked to muscle wasting or loss of muscle function 240,241