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Using both immortalised and primary human cells, liraglutide, acyl-GIP, and a dual GLP-1/GIP receptor agonist (MAR709) failed to produce measurable effects on lipid accumulation, fibrogenic gene expression, or CREB phosphorylation at physiologically relevant concentrations

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Window 6 weeks What Was Measured Improved ejection fraction, reduced fibrosis, and increased survival in pressure-overload heart failure

110 This dynamic equilibrium between CSCs and non-CSCs makes it difficult to eradicate CSCs by targeting specific markers, as non-CSCs can also repopulate tumors