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In anaesthetized pigs, neither cervical vagotomy, adrenergic blockers (alpha, beta, or combined alpha-beta blockade), ganglionic blockade (hexamethonium), nor inhibition of hyperpolarization-activated cyclic nucleotidegated (HCN) channels (ivabradine) abolished the marked chronotropic effect of GLP-1

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Its common that feelings of fatigue and tiredness will reduce after a week or two once the body adapts to the reduced calorie intake and change in metabolism

Rodriguez HA, Ackerman LV