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Heres what makes them different: PPIs like omeprazole (Prilosec), esomeprazole (Nexium), and pantoprazole (Protonix) work by: | Treatment | Mechanism | Duration | Effectiveness for GLP-1 Users | Availability | |||-|-|| | Calcium Antacids (Tums, Rolaids) | Neutralizes existing acid | 30-60 minutes | Low-Moderate | OTC | | H2 Blockers (Pepcid, Tagamet) | Reduces acid production | 4-8 hours | Moderate | OTC & Prescription | | PPIs (Prilosec, Omeprazole) | Blocks acid pumps | 24+ hours | High | OTC & Prescription | | Alginates (Gaviscon) | Forms protective barrier | 4 hours | Moderate | OTC | | Combination Approaches | Multiple mechanisms | Varies | High | Varies | Many Klarity Health patients have found success with a proactive approach to managing GLP-1-related heartburn: Some healthcare providers recommend starting a PPI like omeprazole before heartburn symptoms develop, especially if you have a history of acid reflux

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